NICE Guidance (see drug-specific links below)
For cystic-fibrosis, these drugs are available from a specialist centre only.
Dornase alfa is approved for intrapleural use by a respiratory consultant for the management of pleural infection in adults (unlicensed indication and route) only when surgery/transfer to tertiary care is not an option. It is to be requested from pharmacy on an individual patient basis only with the understanding that it will take 3-4 working days to obtain as it is not routinely stocked.
