Narcolepsy
November 2020: Modafinil (Provigil): increased risk of congenital malformations if used during pregnancy
Drugs used in the treatment of narcolepsy include dexamfetamine and methyphenindate. Treatment choice would be led by a specialist.
Solriamfetol can only be prescribed at a tertiary specialist centre with expertise in treating narcolepsy and in accordance with the NICE guidance below.
NICE Guidance
TA758: Solriamfetol for treating excessive daytime sleepiness caused by narcolepsy, January 2022
TA777: Solriamfetol for treating excessive daytime sleepiness caused by obstructive sleep apnoea, March 2022
Also approved for the treatment of fatigue in Multiple Sclerosis (off-label use) as per NICE guideline NG220.
This should be 2nd line treatment where patients have already tried amantadine and it has been ineffective, or where patients have struggled with side-effects or have had an allergic reaction to amantadine.
To be initiated by Consultant Neurologist only.
| Pack |
|---|
| 30 tablet |
- On Formulary Preferred
- On Formulary Second Line
- On Formulary Third Line
- Specialist Initiation
- Secondary Care Only
- Not Approved for Formulary