Migraine
Drug Safety Update
January 2026: Botulinum toxin type A products: updated warnings regarding risk of iatrogenic botulism
September 2025: Paracetamol and pregnancy - reminder that taking paracetamol during pregnancy remains safe
June 2023: Non-steroidal anti-inflammatory drugs (NSAIDs): potential risks following prolonged use after 20 weeks of pregnancy
January 2017: Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen; possible need for continued treatment with NAC.
December 2014: Treating paracetamol overdose with intravenous acetylcysteine: new guidance
NICE Guidance (see also drug specific links below)
CG150 Headaches in over 12s: diagnosis and management
TA260 Botulinium toxin type A for the prevention of headaches in adults with chronic migraine, June 2012
Other drugs used in the treatment of migraine particularly prophylaxis against an attack include propranolol, topiramate, gabapentin and botulinum toxin.
See here for SERMOG Anti-CGRP and botulinum toxin type A migraine prevention pathway
Note: Migraine services in East Kent are currently provided by Bethesda Medical Centre, NOT East Kent Hospitals University NHS Foundation Trust
| Pack |
|---|
| 100 tablet |
| 100 tablet (10 x 10 tablets) |
| 1000 tablet |
| 16 tablet (2 x 8 tablets) |
| 30 tablet (3 x 10 tablets) |
| 32 tablet |
| Pack |
|---|
| 100 capsule (10 x 10 capsules) |
| 16 capsule |
| 32 capsule |
| Pack |
|---|
| 100 tablet (10 x 10 tablets) |
| 24 tablet (4 x 6 tablets) |
| 60 tablet |
| Pack |
|---|
| 100 ml |
| 500 ml |
| Pack |
|---|
| 100 ml |
| 1000 ml |
| 200 ml |
| Pack |
|---|
| 100 ml |
| 500 ml |
| Pack |
|---|
| 100 ml |
| 1000 ml |
| 200 ml |
| 500 ml |
| Pack |
|---|
| 10 suppository |
| Pack |
|---|
| 10 suppository |
| Pack |
|---|
| 10 suppository (2 x 5 suppositories) |
| Pack |
|---|
| 10 suppository (2 x 5 suppositories) |
| Pack |
|---|
| 10 vial |
| Pack |
|---|
| 32 tablet (4 x 8 tablets) |
| 100 tablet |
| Pack |
|---|
| 10 suppository |
| Pack |
|---|
| 10 suppository |
| Pack |
|---|
| 24 tablet |
| 48 tablet (4 x 12 tablets) |
| 84 tablet |
| Pack |
|---|
| 24 tablet |
| 48 tablet (4 x 12 tablets) |
| 84 tablet (7 x 12 tablets) |
| Pack |
|---|
| 100 ml |
| 150 ml |
| 500 ml |
| Pack |
|---|
| 60 tablet |
| 28 tablet |
| 84 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 3 tablet |
| 6 tablet |
| Pack |
|---|
| 12 tablet |
| 2 tablet |
| 3 tablet |
| 6 tablet |
| Pack |
|---|
| 3 tablet |
| 6 tablet |
| Pack |
|---|
| 12 tablet |
| 2 tablet |
| 4 tablet |
| 6 tablet |
| Pack |
|---|
| 12 tablet |
| 2 tablet |
| 4 tablet |
| 6 tablet |
| Pack |
|---|
| 2 unit dose |
| Pack |
|---|
| 2 pre-filled disposable injection |
| Pack |
|---|
| 12 tablet (2 x 6 tablets) |
| 6 tablet |
| Pack |
|---|
| 6 tablet |
| Pack |
|---|
| 6 tablet |
| Pack |
|---|
| 6 tablet |
| Pack |
|---|
| 6 unit dose |
Prescribing of atogepant for treatment of migraine can take place in primary care or secondary care. If prescribing for treatment of migraine in secondary care a Blueteq form is required. A Blueteq form in not required for prescribing in primary care.
| Pack |
|---|
| 28 tablet |
| 7 tablet |
| 2 tablet |
In accordance with NICE TA919
See here for K&M Rimegepant Prescribing Guideline for Primary Care
Prescribing of rimegepant for treatment of migraine can take place in primary care or secondary care. If prescribing for treatment of migraine in secondary care a Blueteq form is required. A Blueteq form in not required for prescribing in primary care.
| Pack |
|---|
| 2 tablet |
| 8 tablet |
Prescribing of atogepant for prevention/prophylaxis of migraine must be initiated by a specialist (secondary care and specialist community providers) and requires a Blueteq form. Once stable, subsequent prescribing can be transferred to the GP and does not require a Blueteq form.
Reduce dose to 10 mg once daily with concurrent use of potent CYP3A4 inhibitors, OATP inhibitors, or telmisartan.
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
In accordance with NICE TA919
See here for K&M Rimegepant Prescribing Guideline for Primary Care
| Pack |
|---|
| 2 tablet |
| 8 tablet |
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
Migraine prophylaxis - specialist neurologist prescribing only
| Pack |
|---|
| 1 capsule |
- On Formulary Preferred
- On Formulary Second Line
- On Formulary Third Line
- Specialist Initiation
- Secondary Care Only
- Not Approved for Formulary