Antidepressants - Tricyclic

Tricyclics are inappropriate for initiation as first-line antidepressant treatment (higher risk of adverse drug reactions with TCAs than with SSRIs or SNRIs).

NICE guidance

NG222: Depression in adults recognition and management, updated April 2018

 CG31 Obsessive compulsive disorder November 2005

Kent and Medway NHS and Social Care Partnership (KMPT) Formulary has detailed prescribing information for the treatment of depression

 Depression

Lofepramine is safer in overdose and less cardiotoxic than older tricyclics and is the first-choice if a tricyclic is indicated

Pack
100 capsule
28 capsule
84 capsule
Pack
100 capsule
28 capsule
84 capsule
Pack
100 capsule
28 capsule
56 capsule

Restricted to initiation by specialist only.

Pack
28 tablet
250 tablet
Pack
28 tablet
500 tablet
84 tablet
100 tablet
Pack
150 ml

Restricted to initiation by specialist only.

Pack
100 tablet
30 tablet
28 tablet
84 tablet
Pack
100 tablet
25 tablet
30 tablet
28 tablet
84 tablet
Pack
30 tablet
  • On Formulary Preferred
  • On Formulary Second Line
  • On Formulary Third Line
  • Specialist Initiation
  • Secondary Care Only
  • Not Approved for Formulary