Topical NSAIDs may provide some relief of pain in musculoskeletal conditions.
Topical application of large amounts may result in systemic effects including hypersensitivity and asthma.
NICE guidance for the management of osteoarthritis advises using paracetamol and/or topical NSAIDs before offering oral NSAID treatment.
For acute pain (sprains, strains etc): Use ibuprofen gel first line.
For chronic pain (mainly osteoarthritis): Ketoprofen gel is the most effective and has the least adverse effects.
