Gastro-intestinal smooth muscle spasms

Drug Safety Update

  December 2017: Eluxadoline : risk of pancreatitis; do not use in patients who have undergone cholecystectomy or in those with bilary disorders.

  February 2017: Hyoscine butylbromide injection should be used with caution in patients with cardiac disease and is contraindicated in patients with tachycardia. 

NICE Guidance (also see drug specific links below)

CG61: Irritable bowel syndrome in adults: diagnosis and management, February 2008 (updated April 2017)

Local Guidance

Please see here for K&M ICB Position Statement – GI Anti-spasmodics: Dicycloverine and Propantheline prescribing not supported

  • On Formulary Preferred
  • On Formulary Second Line
  • On Formulary Third Line
  • Specialist Initiation
  • Secondary Care Only
  • Not Approved for Formulary