Corticosteroids with Anti-infective (ear)

Drug Safety Update

Important safety information (for all aminoglycosides)

In view of ototoxicity, the CSM has issued a reminder that treatment with a topical aminoglycoside antibiotic is contraindicated in those with a tympanic (ear drum) performation or patent grommet.

 May 2024: Topical steroids: introduction of new labelling and a reminder of the possibility of severe side effects, including Topical Steroid Withdrawal Reactions

January 2021: Aminoglycosides (gentamicin, amikacin, tobramycin, and neomycin): increased risk of deafness in patients with mitochondrial mutations

   August 2017: Corticosteroids: rare risk of central serous chorioretinopathy with local as well as systemic administration. Local administration includes inhaled, intranasal, epidural, intraarticular, topical dermal and periocular routes. Advise patients to report any blurred vision or other visual disturbances. 

For the general actions, warnings and prescribing notes for steroids, see Corticosteroid responsive conditions

  • On Formulary Preferred
  • On Formulary Second Line
  • On Formulary Third Line
  • Specialist Initiation
  • Secondary Care Only
  • Not Approved for Formulary