Lipid regulating drugs
Drug Safety Update
January 2024: Omega-3-acid ethyl ester medicines (Omacor/Teromeg 1000mg capsules): dose-dependent increased risk of atrial fibrillation in patients with established cardiovascular diseases or cardiovascular risk factors
September 2023: Statins: very infrequent reports of myasthenia gravis
May 2014: Statins: benefits and risks
August 2012: and October 2012 Updated advice on simvastatin interactions and co-prescribing with diltiazem or amlodipine
January 2012: Statins risk of hyperglycaemia and diabetes
December 2010: Fibrates first line treatment not recommended except for those with severe hypertriglyceridaemia
May 2010: Simvastatin increased risk of myopathy at high doses (80mg)
February 2008: Statins - additional side effects including depression, sleep disturbance, memory loss, interstitial lung disease, and sexual dysfunction
January 2008: Statin interactions and updated advice for atorvastatin
NICE Guidance (also see drug-specific links below)
Summary of National Guidance for Lipid Management for Primary and Secondary Prevention of CVD
NG238: Cardiovascular disease, risk assessment and reduction, including lipid modification, December 2023
CG71: Familial hypercholesterolaemia: identification and management
NICE TAs
Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia NICE TA 694, April 2021
Inclisiran for treating primary hypercholesterolaemia or mixed dyslipidaemia, NICE TA 733, October 2021
Icosapent ethyl with statin therapy for reducing the risk of cardiovascular events in people with raised triglycerides NICE TA 805, July 2022
Local guidance
Colestyramine is an anion exchange resin and interferes with the absorption of other drugs. Other drugs should be taken at least 1 hour (ezetimibe 2 hours) before or 4-6 hours after taking colestyramine.
| Pack |
|---|
| 100 tablet |
| 14 tablet |
| 28 tablet |
| 30 tablet |
| 84 tablet |
| 90 tablet |
| Pack |
|---|
| 10 tablet |
| 14 tablet |
| 28 tablet |
| 30 tablet |
| 84 tablet |
| 90 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 90 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 90 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 90 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 98 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 98 tablet |
| Pack |
|---|
| 28 tablet |
Ezetimibe is only indicated for the treatment of primary heterozygous (familial and non-familial) hypercholesterolaemia where statins are contraindicated or not tolerated. Ezetimibe may be co-adminstered with a statin where response has not been adequate or increased doses of statin have not been tolerated.
| Pack |
|---|
| 28 tablet |
| 30 tablet |
To be prescribed according to NICE TA 805 (see link above).
| Pack |
|---|
| 120 capsule |
Bempedoic acid is recommended only in combination with ezetimbe. They may be prescribed as separate tablets or as the fixed dose combination.
| Pack |
|---|
| 28 tablet (2 x 14 tablets) |
Bempedoic acid is recommended only in combination with ezetimbe. They may be prescribed as separate tablets or as the fixed dose combination.
| Pack |
|---|
| 28 tablet |
To be prescribed according to NICE TA 733 (see link above) and K&M ICB Position Statement (see here)
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 100 tablet |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| Pack |
|---|
| 60 capsule |
| 90 capsule |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| Pack |
|---|
| 28 capsule |
| 30 capsule |
| Pack |
|---|
| 28 capsule |
| 30 capsule |
| Pack |
|---|
| 50 sachet |
| Pack |
|---|
| 50 sachet |
Specialist use only - Omega-3-Acid Ethyl Esters for management of Hypertriglyceridemia on recommendation of a Consultant Lipidologist only.
| Pack |
|---|
| 28 capsule |
| 100 capsule |
| 90 capsule |
| Pack |
|---|
| 1 pre-filled disposable injection |
| 2 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
| 2 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 2 pre-filled disposable injection |
- On Formulary Preferred
- On Formulary Second Line
- On Formulary Third Line
- Specialist Initiation
- Secondary Care Only
- Not Approved for Formulary